While racing against the next generation of race cars, including Jackson Storm (Armie Hammer), many begin questioning if the famous Lightning McQueen (Owen Wilson) will retire after he endures a terrible crash. McQueen's sponsor, Rust-eze, is bought by Sterling (Nathan Fillion), who wants to turn him into a racing brand. Lightning asks for a chance to race in the Florida 500 and begins to train with race technician Cruz Ramirez (Cristela Alonzo), who's always had her own racing dreams.

Following the events of Captain America: Civil War (2016), Peter Parker attempts to balance his life in high school with his career as the web-slinging superhero Spider-Man.