Following the latest Ghostface killings, the four survivors leave Woodsboro behind and start a fresh chapter. In Scream VI, Melissa Barrera (“Sam Carpenter”), Jasmin Savoy Brown (“Mindy Meeks-Martin”), Mason Gooding (“Chad Meeks-Martin”), Jenna Ortega (“Tara Carpenter”), Hayden Panettiere (“Kirby Reed”) and Courteney Cox (“Gale Weathers”) return to their roles in the franchise alongside Jack Champion, Henry Czerny, Liana Liberato, Dermot Mulroney, Devyn Nekoda, Tony Revolori, Josh Segarra, and Samara Weaving.

Leo and Angela Russo live a simple life in Queens, surrounded by their overbearing Italian-American family. When their son 'Sticks' finds success on his high school basketball team, Leo tears the family apart trying to make it happen.